<International Circulation>: One indication of fondaparinux is for the prophylaxis of deep vein thrombosis which may lead to pulmonary embolism. We all know that DVT is a major complication in some patients with big surgery such as abdominal surgery， hip replacement， or knee replacement surgery and more. In China， Seldom to prescribe anticoagulant agents to these patients is often due to physicians’ perceiving the risk of major bleeding in association with anticoagulant therapy as unacceptably high. What is the status of anticoagulant for the prophylaxis of DVI in USA at present? Would you like to share us your experience of fondaparinux or other anticoagulants for the prophylaxis of deep vein thrombosis?
《国际循环》：磺达肝癸钠的一个适应证是预防深静脉血栓，后者可导致肺栓塞。我们知道深静脉血栓也是许多大手术患者的一个主要并发症，如腹部手术、髋关节或膝关节置换。在中国，医生们由于担心抗凝治疗引起大出血的风险将会很高，而很少对上述患者应用抗凝药。美国应用抗凝药预防深静脉血栓的情况如何？能否与我们一同分享您在使用磺达肝癸钠等抗凝药预防深静脉血栓方面的经验？
Prof.Samuel Z. Goldhaber: In the US， DVT and pulmonary embolism are the third major cause of cardiovascular death and disability...
4. <International Circulation>: Oasis 5 and 6 fondaparinux showed some benefit over the antithrombotic agents in ACS. Patients with or without ST segment elevation expect those who priamary PCI， since 2007 ENEA has approved the use of fondaparinux for the treatment of ACS， but however fondaparinux is not yet FDA approved. Which are used in patients with coronary thrombosis in US. What is your opinion about this difference， so do you agree with fondaparinux for the treatment of ACS.
《国际循环》：OASIS-5显示磺达肝癸钠和依诺肝素在减少非ST抬高急性冠脉综合征患者心脏事件的作用相似，但前者的出血显著减少，这种净效在药物组及介入组均能见到。但是OASIS-6表明直接PCI的ST抬高型急性冠脉综合征患者，磺达肝癸钠组的导管血栓和其他冠脉并发症更多见。为什么应用磺达肝癸钠的介入患者会存在上述不同结果？PCI患者应用磺达肝癸钠是否安全？如果PCI前已应用了磺达肝癸钠，应该如何避免上述并发症？
Prof.Samuel Z. Goldhaber: So I think the differe
nt agencies work at different speeds. This time the Europe is a little faster than the US. And sometimes the US is a little faster than the Europe. To me it’s not so important， I don’t think there is any major problem with that. In flunctuates， just like the value against of the dollar against the Euro fluctuates day to day. But the dollar against the Wan or the YAN. I think it’s going to fluctuate.
Samuel Z. Goldhaber教授：我认为不同机构的工作速度存在差异。这次欧洲的速度比美国稍快。有时，美国又稍领先于欧洲。对我来说，这并不是什么大的问题。就像欧元对美元的汇率每天都会有波动，同时美元对韩
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