<International Circulation>: Sometimes the same clinical trial can have different conclusions， including meta-analysis. What is your opinion of this situation? How can we get the most useful information from the literature?

Dr. Granada: This is why you must pay attention to the type of study you are examining. There are randomized clinical studies and what we call real life experiences， which are the registries. In terms of meta-analysis， you must be careful because the conclusion lies in the eye of the beholder and how you want to analyze the data.