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[CIT2012]新一代DES的研发方向——Stephan Windecker教授访谈

作者:  StephanWindecker   日期:2012/3/28 17:04:14

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大多数当前研发中并将在不远的将来上市的平台,都使用生物可降解聚合物。原因在于使用这种支架,可在一定时间内获得药物的直接释放,并且兼具高度的有效性和良好的安全性。

  International Circulation: You mentioned stents that require no anti-thrombotic medication; what would we need to do to a stent in order to make it not require anti-thrombotic medication?
  Stephan Windecker:  The ideal stent would not require any anti-platelet therapy and you would not worry about latent discontinuation of such therapy.  At this point this is just a dream.  We should always be looking for an ideal platform that would achieve this it would be a very promising one.
  《国际循环》:您提到不需要抗栓治疗的支架,我们需要对支架作哪些改进才能达到这一目的?
  Stephan Windecker:理想的支架不需要任何抗血小板治疗,你无需再担心抗栓治疗中断的可能。但目前这还只是一个梦想。我们会一直寻求能够实现这一理想的平台,这个设想有着非常光明的前景。
  International Circulation:  One platform approaching the ideal one may be the completely bioabsorbable scaffolding.  How far away do you think that is?  And do you think that such a platform is worth going after?
  Stephan Windecker:  The scaffolding platform is already available in clinical trials and is available commercially in Europe and has CE approval.  The technology is already here to be used and in the next few years we will better define the indications for its use and better understand whether it offers additional value beyond the already used polymer-based DES.
  《国际循环》:最接近理想的平台可能是完全生物可吸收支架,您认为我们还有多远的路要走?您认为这一平台值得进一步研究吗?
  Stephan Windecker:该支架平台已经在进行临床试验,且在欧洲已经上市并获得CE批准。这项技术已经进入临床应用,在未来几年内我们将更好地定义其适应证,更好地理解其是否能带来超过当前基于聚合物的DES的更大价值。
  International Circulation:  That is just it, so far it hasn’t been proven to be of any additional value clinically.
  Stephan Windecker:  It is a completely new technology and has many ongoing studies to address these questions in organized trials.  It takes that effort and the natural course of conducting studies to know these things.
  《国际循环》:就是说,目前尚未证实其有任何额外的临床价值?
  Stephan Windecker:这是一项全新的技术,有多项临床试验正在进行中,试图回答上述问题。通过实施研究才可以获得更多信息。
  International Circulation:  Do you think there are any improvements that need to be made in order to make it better or do you think that we just need more time to be able to see the improvement?
  Stephan Windecker:  There will be improvements on this technology.  Currently it is quite thick because of the material properties.   In the future there will certainly be developments in the direction of making scaffolding thinner.  It is just a novel technology that is still in its infancy.
  《国际循环》:您是否认为还需要做出一些改进以使其变得更好,还是只是需要更多时间以看到结果的改善?
  Stephan Windecker:这项技术将会不断完善。目前由于所使用的材料特性所限,支架结构还比较厚。未来会随着技术发展,使支架平台变得更薄。这是一项崭新的技术,可以说还处在“婴儿”阶段。

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