International Circulation: With the elderly， what extra considerations would you make for DAPT treatment?
　　Dr. Mehran: The elderly are extremely prone to major bleeding that may be minor for younger populations. It is very important to follow those patients， to think about how to apply non-bleeding or bleeding-protective therapies on those patients， because bleeding is extremely important. A bleed can kill these patients. We also do not want to be vigilant that we actually ration care to them and not give them life saving therapy. There is a fine balance between the risks and the benefits for those patients.
　　《国际循环》：对老年患者，DAPT有什么特殊之处吗？
　　Mehran教授：老年人出血风险高于年龄教轻者。对老年患者坚持随访很重要，还应该考虑使用出血保护或不出血的方法。出血是一件很严重的事，可致人死亡，我们愿意尽一切可能以避免这种后果。但我们也必须不过份紧张，不给予他们可以挽救生命的治疗（DAPT）。在获益和风险之间要找到最佳平衡点。
　　International Circulation: As a physician trying to understand the risks and benefits， though have no trials that focus on elderly patients， how do you apply the data?
　　Dr. Mehran: It is difficult， because at the end of the day， both the elderly and women comprise a minority. We do not have enough data and need more disparity data. The elderly belong in the disparity group. We have to promote the inclusion of these patients. Otherwise， you have to use your clinical judgment. It is the art of medicine.
　　《国际循环》：大多数的临床使用没有纳入老年患者，医生该如何寻找最佳平衡点呢？
　　Mehran教授：这确实很困难。老年人、女性是少数，我们没有足够的数据，但我们需要这些不同人群的数据。我们必须推进在临床试验中纳入老年人，纳入女性。在目前缺乏证据的情况下，医生只有运用自己的判断，这是医学艺术。