<International Circulation>: Are there any recent primary prevention trials about sudden cardiac death?

  《国际循环》：近期有关于心源性猝死的一级预防的试验吗？

    Dr Iwai:  Unfortunately there haven’t been any large notable trials since SCD-HeFT (which was published back in 2009) that have really helped us to drive the primary prevention population. Although we are worried about this population， at this point there are no active trials. There was a trial which was terminated due to a lack of enrollment or difficulties with enrollment called DETERMINE and that was a very exciting trial that looked at cardiac magnetic resonance imaging looking at infarct mass as a more powerful predictor potentially of sudden cardiac death and mortality in this population. It was really aimed to also compare it with echocardiogram assessment of ejection fraction to see which performed better.

    Iwai博士：不幸的是，自从SCD-HEFT （早在2009年发表）试验后，没有任何大规模的著名试验真正帮助我们来推动一级预防人群。尽管我们为这一人群担忧，但此刻尚无积极的试验。DETERMINE试验因为招募人数不足或招募困难而被终止，这是一项令人非常兴奋的试验，利用心脏MRI，将梗死心肌重量作为这一人群心源性猝死和死亡率的可能更有效的预测因子。该试验还将比较梗死心肌重量与经超声心动图评估的EF的，以观察哪种指标更好。