International Circulation:  Can you talk about your view or your opinion about a single pill combination in antihypertensive therapy?

《国际循环》：您能就抗血压治疗中单片联合谈谈您的观点吗？

Professor Unger:  Single pill combination means that several different drug components are contained in one single pill.  Since we use five or six different classes of drugs  in hypertension， we  add them to each other in different types of combination in one single pill.  Some of these single pill combinations make probably more sense than others and have been employed in treating patients for many years now.  I think of course of the combination of the ACE inhibitor with a diuretic or an  AT1 receptor antagonist (ARB) with a diuretic.  In the more recent past， fixedcombinations of an ARB or ACE inhibitor with a calcium antagonist have been introduced， and that also seems to be quite a good combination.  Going further，， one can even combine three antihypertensive components in a single pill， for instance an ARB， a diuretic， and a calcium antagonist.  So there are many possibilities of combining between the five drug classes that we have in treating hypertension. 

Unger教授：单片联合的意思是几种不同的药物成分包含在单个的药片中。因为我们在高血压治疗中应用了5种或6种药物，我们在单个药片中将这些药物以不同的联合方式相互添加。这些单片联合中的一些联合可能较其他联合更有意义，且多年来已经被用于治疗患者。我认为，这些联合中当然包括ACE抑制剂联合利尿剂或AT1受体拮抗剂（ARB）联合利尿剂。最近，对ARB或ACE抑制剂与钙通道阻滞剂的固定复方联合已经有所介绍，看起来也是一种非常好的联合。进一步说，我们甚至可以将3种抗高血压药物联合在单个药片中，例如一种ARB、一种利尿剂和一种钙通道阻滞剂。因此，在高血压治疗中，我们在5种药物种类之间进行联合存在多种可能性。

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