International Circulation:  Regarding treatment with these new， direct renin inhibitors， much is discussed about plasma renin activity.  Can you explain this for us and provide some details about the mechanisms involved?

国际循环：对直接肾素抑制剂讨论更多的血浆肾素活性。您能解释一下具体机制么？

Professor Zamarano:  The levels of plasma renin activity have been shown to be a clear prognosis marker.  This then opens a new window in treating hypertensive patients with those new agents.  We have seen the advances of trials showing data which allows us to say that direct renin inhibitors are now a new element， a new treatment option to combat hypertension and help prevent organ damage.

Zamarano教授：已证实，血浆肾素活性是诊断标记物，应用直接肾素抑制剂为治疗高血压患者提供新方法。试验数据表明，直接肾素抑制剂是一种降压治疗新的选择、新的治疗观点，并能预防脏器损伤。