<internation circulation>:
With the development odf safe and effective anti-coagulants， how do you foresee the use of anti-platelet drugs?

Holmes:
I think they treat two different aspects of the atherothrombotic disease， called ‘cardio-vascular disease’; they treat two different aspects.     The oral anti-coagulant drugs – the new ones as well as the old ones –  will be used for different indications than will the ant-platelet drugs.