<International Circulation>:Some recent reports also support the traditional viewpoint that patients with diabetes and cardiovascular disease are not good candidates for interventional therapeutics. Should we rule out interventional management in this population?

Donald E. Cutlip ：This is a very important question. The FREEDOM trial is attempting to answer this question specifically in patients with diabetes and multivessel CAD.  There are a number of reasons why patients with diabetes and extensive disease who require revascularization may do better with bypass surgery.  The most important of these is the protection by bypass from impact of disease progression， which is accelerated in patients with diabetes.