<International Circulation>:  Could you please summarize the latest progress of the Hamburg Trial; which is a prospective observation of 2000 healthy workers for the development of metabolic syndrome?
    Prof. Beisiegel: The aim of the study is to find early biomarkers for insulin resistance and diabetes which should be followed in their relevance over a ten year time period. The recruiting process has just been finalized a few months ago and there are only preliminary data available in the moment. Incidentally we found that in this population of healthy workers only 26% have no risk factor at all. Checking for the five features defined as markers for the metabolic syndrome， namely high waist circumference， high blood pressure， high glucose levels， high triglycerides or low HDL cholesterol， we found 17% with confirmed metabolic syndrome (three of these features). And even though the cohort has a mean age of only 42 years， already 57% expressed one or two of those risk factors. 
    汉堡研究的目的是发现胰岛素抵抗和糖尿病的早期标志物。汉堡研究的受试者入选工作已于几个月前完成，也得到了一些初步数据。健康工人人群只有26%没有糖尿病危险因素。检查作为标志物的代谢综合征的5种特征：过粗腰围、高血压、高血糖、高血脂和低HDL胆固醇，17%的人群符合3个以上特征被确诊为代谢综合征。尽管该组人群平均年龄只有42岁，但57%的人群表现出1个或2个危险因素。
    <International Circulation>:  What is the role of endogenous apolipoprotein E in adipogenic differentiation?
    Prof. Beisiegel: Adipose tissue needs apolipoprotein E for its differentiation and in absence of this apoprotein， as demonstrated in apolipoprotein E protein knockout cells or mice， adipose tissue does not develop normally. This is a very important finding and one of the many physiological functions of apolipoprotein E.
    褐色脂肪组织的分化需要载脂蛋白E。去除载脂蛋白E基因的细胞或小鼠的褐色脂肪组织不能正常发育，这是载脂蛋白E的重要功能之一，也是一个非常重要的发现。